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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Immunoprofiling of leukemic stem cells CD34+/CD38−/CD123+ delineate FLT3/ITD-positive clones

Fig. 4

FLT3/ITD mutations in the BM cells of 7 AML patients. a CD34+/CD38−/CD123+ and CD34+/CD38−/CD123− cells from different patient samples were isolated by sorting (sorting results displayed in Table 4). For each of the seven samples, genomic DNA was isolated from the (1) CD34+/CD38−/CD123−, (2) CD34+/CD38−/CD123+ cells, and (3) unsorted cells at diagnosis (a vertical line was inserted to indicate that diagnosis samples were done on separate gels). b The sequences of the FLT3/ITD mutations from the two samples (patients 3 and 4) are shown. These sequences, obtained from the DNA of CD34+/CD38−/CD123+ cells, matched the sequences of the mutations present in the pre-sorted samples. bp indicates base pair. Boldface sequence refers to the inserted, duplicated material

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