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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: MiR-124-3p/B4GALT1 axis plays an important role in SOCS3-regulated growth and chemo-sensitivity of CML

Fig. 5

SOCS3 regulated the expression of miR-124-3p in CML cells. The relative mRNA levels of SOCS3 or miR-124-3p in K562 and KU812 cells were analyzed by q-PCR after SOCS3 over-expression (a) or knock-down (b). Each value was the mean ± SD of three experiments (n = 3),*P < 0.05; compared with standard. c Relative mRNA levels of miR-124-3p in K562 and KU812 cells that were stably transduced with shSOCS3 or shControl vector were examined at 48 h following imatinib treatment. Results were normalized to untreated cells. RNU6-2 was served as an internal control. Each value was the mean ± SD of three experiments (n = 3), *P < 0.05; compared with shControl. d Statistically significant correlation between miR-124-3p and SOCS3 expression was observed by Pearson’s method. The y-axis or x-axis represented the relative mRNA levels of miR-124-3p or SOCS3 in BMNCs from 30 CML patients, which were normalized against internal control RNU6-2 or β-Actin. Each point represented the mean of three independent experiments (n = 3). Data are expressed as the mean ± SD

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