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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway

Fig. 6

Combination of trastuzumab and oxamate effectively inhibited tumor growth and the Warburg effect in vivo. a Pre-established NCI-N87 tumor xenografts were treated with Ttzm (10 mg/kg,i.p., 2 times/wk × 3 weeks), OX (750 mg/kg,i.p.,daily for 21 days), or a combination of the agents. Arrow means begin to treat drugs. Data are presented as the tumor volume (mm3), n = 6. Statistical analysis of the differences of average tumor sizes in the Ttzm treatment group and the combination group was performed using the multiple t test. *P < 0.05, # P < 0.01, + P < 0.001. b Representative IHC TUNEL staining of tissue from mice bearing NCI-N87 xenografts pretreatment with PBS, OX, Ttzm, and Ttzm plus OX. c MicroPET demonstrates that trastuzumab plus oxemate inhibit 18F-FDG uptake most effectively in mice bearing NCI-N87 xenograft. R, right (MACC1 overexpression or downregulation); L, left (vector or scramble). White circle presents the tumor location

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