Fig. 7From: A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathwayDiagram summarizing the proposed mechanism by which MACC1 drives resistance to trastuzumab. MACC1 promotes the Warburg effect through the PI3K/AKT signaling pathway. Both the activation of PI3K/AKT pathway and the enhancement of the Warburg effect induce the resistance to trastuzumab in HER2-positive GCBack to article page