Fig. 2

Possible targeted therapies for the treatment of HCC. a HCC tumor treatment modalities with CSC mediated treatment initially result in tumor shrinkage and regression due to the elimination of CSCs. Some residual non-CSCs undergo EMT leading to repopulation of CSCs, subsequently resulting in treatment failure and metastasis. b CSC and EMT therapies comprising of treatments targeting CSC and EMT phenotypes with monoclonal antibodies, pathway inhibitors, miRNAs, or immunotherapy potentially leads to improved outcomes