TY - JOUR AU - Tian, Yijun AU - Wu, Kongming AU - Liu, Qian AU - Han, Na AU - Zhang, Li AU - Chu, Qian AU - Chen, Yuan PY - 2016 DA - 2016/09/06 TI - Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer JO - Journal of Hematology & Oncology SP - 83 VL - 9 IS - 1 AB - The objective of this study was to evaluate the effect of platinum-based drugs on nuclear-factor erythroid2 like 2 (NRF2) signaling in non-small cell lung cancer cell lines with or without Kelch-like ECH-associated protein 1 (KEAP1) mutations and to determine the role of NRF2 and KEAP1 on platinum-based drug treatment. SN - 1756-8722 UR - https://doi.org/10.1186/s13045-016-0311-0 DO - 10.1186/s13045-016-0311-0 ID - Tian2016 ER -