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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer

Fig. 3

KEAP1 overexpression inhibits NRF2 signaling and increases chemosensitivity to nedaplatin or cisplatin in KEAP1-mutant cells. a, b mRNA and protein levels of NRF2-regulated genes in A549 cells overexpressing wild-type KEAP1. c, d KEAP1 overexpression modified the sensitivity of A549 cells to platinum-based drugs. e, f mRNA and protein levels of NRF2 downstream genes in H460 cells overexpressing wild-type KEAP1. g, h KEAP1 overexpression modified the sensitivity of H460 cells to platinum-based drugs. The results are presented as the mean ± SEM. *p < 0.001, **p < 0.05. Vec vector

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