Fig. 4
From: Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer
KEAP1 mutations activate NRF2 signaling and confer chemo-resistance. a, b KEAP1 with the G333C or D236H mutations induced the expression of NRF2 downstream target genes at the mRNA and protein levels in H292 cells. c, d KEAP1 with the G333C or D236H mutations increased cell survival in H292 cells exposed to 60-μm platinum-based drugs. e, f KEAP1 with the G333C or D236H mutation induced the expression of NRF2-associated genes at the mRNA and protein levels in SKMES-1 cells. g, h KEAP1 with the G333C or D236H mutation increased cell survival in SKMES-1 cells exposed to 60-μm platinum-based drugs. The results are presented as the mean ± SEM. *p < 0.001, **p < 0.05. Vec vector