Fig. 5
From: Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer
siRNA inhibited NRF2 signaling and increased chemosensitivity to platinum-based drugs. a, b siRNA knockdown of NRF2 reduced the expression of NRF2 and NRF2-regulated genes at the mRNA and protein levels in H292 cells. c, d siRNA increased the sensitivity of H292 cells to platinum-based drugs. e, f siRNA targeting NRF2 reduced the expression of NRF2 and NRF2-associated genes at the mRNA and protein levels in SKMES-1 cells. g, h siRNA knockdown of NRF2 increased platinum sensitivity in SKMES-1 cells. The results are presented as the mean ± SEM. *p < 0.001, **p < 0.05. Vec vector