Fig. 7
From: Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer
Comparison of NRF2-associated genes mRNA between KEAP1-wt and KEAP1-mut cases in squamous lung cancer. a NRF2 mRNA expression levels in KEAP1-wt and KEAP1-mut cases. b KEAP1 mRNA expression levels in KEAP1-wt and KEAP1-mut cases. c HO1 mRNA levels between KEAP1-wt and KEAP1-mut cases. d NQO1 mRNA levels in KEAP1-wt and KEAP1-mut cases. e GCLM mRNA expression levels in KEAP1-wt and KEAP1-mut cases. f Schematic diagram of wild-type (left) and mutant KEAP1 protein (right) function. Mutant KEAP1 was predicted to exhibit an attenuated unity. The increased nuclear accumulation and transcriptional activity of NRF2 upregulate the expression of cytoprotective genes such as HO1, NQO1, and GCLM, thereby leading to cancer cell chemo-resistance. BTB, broad complex, tramtrack, and Bric à brac, IVR intervention region, wt wild type, mut mutation. The results are presented as the median ± quartile