Fig. 1
From: Second-generation inhibitors of Bruton tyrosine kinase
The structure of Bruton tyrosine kinase (BTK). BTK has a pleckstrin-homology (PH) domain, SH3 and SH2 (src-homology) domains, and a kinase domain. The BTK polypeptide has 659 amino acid residues with an approximate molecular weight of 76Â kDa. The C481S mutation in the kinase domain mediates resistance to ibrutinib