From: Second-generation inhibitors of Bruton tyrosine kinase
 | Ibrutinib | ACP-196 | ONO/GS-4059 | BGB-3111 |
---|---|---|---|---|
Target | BTK | BTK | BTK | BTK |
Major off-targets | EGFR, ITK, TEC | Minimal | TEC (weak) | ITK (weak) |
Activity on C481S | No | Yes | Yes | Yes |
Platelet inhibition | Yes | No | NA | NA |
Atrial fibrillation | Observed | Not observed | Observeda | NA |
Approved indications | CLL/SLL, MCL,WM | None | None | None |