|
Clinical features
|
Initial diagnosis
|
refractoriness
|
|---|
|
Number (n = 28)/percentage (%)
|
Number (n = 28)/percentage (%)
|
|---|
|
Fever
|
28/100.0
|
28/100.0
|
|
Neutrophils <1 × 109/L
|
15/53.6
|
13/46.4
|
|
Hgb <90 g/L
|
16/57.1
|
18/64.3
|
|
PLT <100 × 109/L
|
23/82.1
|
25/89.3
|
|
TG >3 mmol/L
|
17/60.7
|
18/64.3
|
|
Fgb <1.5 g/L
|
10/35.7
|
16/57.1
|
|
Ferritin ≥500 μg/L
|
21/75.0
|
25/89.3
|
|
ALT >40 U/L
|
24/85.7
|
24/85.7
|
|
TBiL >17.1 μmol/L
|
16/57.1
|
18/64.3
|
|
LDH >190 U/L
|
18/64.3
|
21/75.0
|
|
Splenomegaly
|
28/100.0
|
28/100.0
|
|
Hemophagocytosis
|
21/75.0
|
22/78.6
|
|
Decline of NK cell activity
|
17/60.7
|
18/64.3
|
|
Elevated soluble CD25
|
25/89.3
|
28/100.0
|
|
Positive EBV-DNA in whole blood
|
28/100.0
|
28/100.0
|
|
Positive EBER in lymph node/bone marrow
|
3/10.7
|
4/14.3
|
-
Hgb hemoglobin, PLT platelet, Fgb fibrinogen, ALT alanine aminotransferase, TBiL total bilirubin, LDH lactic dehydrogenase
