Table 1 Clinical features of study patients at the time of initial diagnosis and time of identification of refractoriness
Clinical features | Initial diagnosis | refractoriness |
|---|---|---|
Number (n = 28)/percentage (%) | Number (n = 28)/percentage (%) | |
Fever | 28/100.0 | 28/100.0 |
Neutrophils <1 × 109/L | 15/53.6 | 13/46.4 |
Hgb <90 g/L | 16/57.1 | 18/64.3 |
PLT <100 × 109/L | 23/82.1 | 25/89.3 |
TG >3 mmol/L | 17/60.7 | 18/64.3 |
Fgb <1.5 g/L | 10/35.7 | 16/57.1 |
Ferritin ≥500 μg/L | 21/75.0 | 25/89.3 |
ALT >40 U/L | 24/85.7 | 24/85.7 |
TBiL >17.1 μmol/L | 16/57.1 | 18/64.3 |
LDH >190 U/L | 18/64.3 | 21/75.0 |
Splenomegaly | 28/100.0 | 28/100.0 |
Hemophagocytosis | 21/75.0 | 22/78.6 |
Decline of NK cell activity | 17/60.7 | 18/64.3 |
Elevated soluble CD25 | 25/89.3 | 28/100.0 |
Positive EBV-DNA in whole blood | 28/100.0 | 28/100.0 |
Positive EBER in lymph node/bone marrow | 3/10.7 | 4/14.3 |