Table 4 Univariate analysis for TTFT and OS

Binet stage B–C vs A

39 vs 161

9.884 (5.939–16.450)

<0.0001

3.174 (1.677–6.007)

0.0002

CD38 pos vs neg

79 vs 121

4.097 (2.564–6.546)

<0.0001

3.123 (1.686–5.783)

0.0001

IGVH mut vs unmut

105 vs 91

5.584 (3.326–9.374)

<0.0001

3.667 (1.886–7.127)

<0.0001

11q22 deletion yes vs no

20 vs 180

2.879 (1.528–5.426)

0.0006

1.736 (0.739–4.078)

0.2000

TP53 disruption yes/no

19 vs 181

3.284 (1.867–5.781)

<0.0001

4.246 (2.076–8.687)

<0.0001

FISH int-unfav vs fav

58 vs 142

2.605 (1.670–4.063)

<0.0001

2.432 (1.438–4.454)

0.0029

Complex karyotype yes vs no

28 vs 167

2.979 (1.756–5.056)

<0.0001

3.854 (1.961–7.578)

<0.0001

Mutations by NGS no/yes

116 vs 84

2.835 (1.799–4.469)

<0.0001

2.171 (1.176–4.008)

0.0130

 0

116

1

<0.001

1

0.037

 1

47

2.373 (1.369–4.112)

0.002^a

1.936 (0.930–4.032)

0.078^a

 ≥2

37

3.418 (2.009–5.759)

<0.001^a

2.466 (1.187–5.126)

0.016^a

TP53 mut vs wt

16 vs 184

2.804 (1.514–5.194)

0.0010

2.793 (1.284–6.098)

0.0069

NOTCH1 mut vs wt

16 vs 184

2.353 (1.164–4.762)

0.0141

2.646 (1.114–6.259)

0.0219

SF3B1 mut vs wt

15 vs 185

1.779 (0.886–3.571)

0.1006

1.170 (0.419–3.268)

0.7648

ATM mut vs wt

10 vs 190

3.623 (1.715–7.633)

0.0003

1.946 (0.686–5.525)

0.2023

BIRC3 mut vs wt

8 vs 192

0.817 (0.254–2.597)

0.7246

1.099 (0.252–4.808)

0.8998

MYD88 mut vs WT

7 vs 193

1.758 (0.642–4.812)

0.2724

1.505 (0.363–6.240)

0.5733

PTEN mut vs WT

7 vs 193

1.573 (0.574–4.310)

0.3780

1.503 (0.363–6.224)

0.5742

FBXW7 mut vs WT

6 vs 194

1.820 (0.664–4.988)

0.2441

1.445 (0.349–5.986)

0.6134

POT1 mut vs WT

5 vs 195

1.059 (0.259–0.321)

0.9375

0.978 (0.352–4.768)

0.9973

BRAF mut vs WT

5 vs 195

7.730 (3.014–19.827)

<0.0001

2.126 (0.286–15.823)

0.4610

ZMYM3 mut vs WT

5 vs 195

0.484 (0.067–3.480)

0.4710

2.336 (0.563–9.693)

0.2434

OTHERS mut vs wt

19 vs 181

1.036 (0.517–2.075)

0.9205

0.898 (0.320–2.518)

0.8381