Table 5 Multivariate analysis for TTFT and OS

Binet stage b–c vs a

11.206

6.384–19.671

<0.001

5.570–22.545

<0.001

3.080

1.501–6.319

0.002

1.302–7.286

0.010

CD38 pos vs neg

1.141

0.670–1.942

0.627

0.663–1.938

0.634

1.067

0.506–2.249

0.864

0.448–2.356

0.883

11q deletion yes vs no

1.306

0.619–2.755

0.484

0.532–3.205

0.560

Na

Na

Na

Na

Na

TP53 disruption yes vs no

2.255

1.168–4.352

0.015

1.039–4.891

0.040

4.055

1.844–7.917

<0.001

1.897–8.670

<0.001

IGHV unmut vs mut

5.078

2.599–9.554

<0.001

2.491–10.354

<0.001

3.198

1.524–6.13

0.002

1.200–8.522

0.020

 0

1

1

1

1

 1

1.452

0.812–2.594

0.208

0.574–3.673

0.431

0.930

0.417–2.074

0.860

0.348–2.484

0.885

 ≥2

2.791

1.468–5.306

0.002

1.375–5.665

0.004

1.115

0.492–2.523

0.795

0.480–2.589

0.801

Complex karyotype yes vs no

1.649

0.896–3.034

0.108

0.824–3.301

0.158

3.173

1.521–6.619

0.002

1.369–7.355

0.007