Skip to main content

Table 2 Multivariate analysis for patients with AML in primary relapse

From: Unrelated donor versus matched sibling donor in adults with acute myeloid leukemia in first relapse: an ALWP-EBMT study

Variable

HR (95 % CI)

p

RI

 UD vs MSD

0.76 (0.64–0.89)

<0.01

 Agea

0.99 (0.99–1.00)

0.02

 Time from dx to Tx >9 months

0.62 (0.53–0.72)

<0.01

 Female donor to male recipient

0.91 (0.74–1.11)

0.35

 sAML

0.99 (0.79–1.23)

0.92

 previous auto-HSCT

1.22 (0.86–1.73)

0.26

 Positive recipient CMV serology

0.96 (0.80–1.15)

0.68

 Positive donor CMV serology

1.03 (0.86–1.22)

0.77

 RIC

1.21 (1.02–1.42)

0.03

NRM

 UD vs MSD

1.04 (0.80–1.35)

0.79

 Agea

1.02 (1.01–1.03)

<0.01

 Time from dx to Tx >9 months

0.82 (0.64–1.06)

0.12

 Female donor to male recipient

0.86 (0.62–1.21)

0.40

 sAML

1.39 (1.03–1.87)

0.03

 previous auto-HSCT

1.49 (0.91–2.43)

0.11

 Positive recipient CMV serology

0.98 (0.74–1.30)

0.89

 Positive donor CMV serology

0.98 (0.74–1.28)

0.86

 RIC

0.96 (0.74–1.24)

0.74

LFS

 UD vs MSD

0.83 (0.72–0.96)

0.01

 Agea

1.00 (0.99–1.00)

0.82

 Time from dx to Tx >9 months

0.67 (0.59–0.77)

<0.01

 Female donor to male recipient

0.90 (0.75–1.07)

0.22

 sAML

1.11 (0.93–1.32)

0.26

 previous auto-HSCT

1.29 (0.97–1.71)

0.08

 Positive recipient CMV serology

0.97 (0.84–1.13)

0.72

 Positive donor CMV serology

1.01 (0.87–1.17)

0.87

 RIC

1.13 (0.98–1.30)

0.09

OS

 UD vs MSD

0.89 (0.77–1.03)

0.12

 Agea

1.00 (1.00–1.01)

0.36

 Time from dx to Tx >9 months

0.71 (0.61–0.81)

<0.01

 Female donor to male recipient

0.86 (0.72–1.03)

0.10

 sAML

1.09 (0.91–1.31)

0.34

 previous auto-HSCT

1.25 (0.93–1.68)

0.15

 Positive recipient CMV serology

0.96 (0.82–1.12)

0.61

 Positive donor CMV serology

0.99 (0.85–1.16)

0.92

 RIC

1.01 (0.88–1.17)

0.88

  1. Abbreviations: HR hazard ratio, CI confidence interval, RI relapse incidence, NRM non-relapse mortality, LFS leukemiafree survival, OS overall survival, UD unrelated donor, MSD matched sibling donor, cont continuous, dx diagnosis, tx transplant, sAML secondary acute myeloid leukemia, auto-HSCT autologous hematopoietic stem cell transplantation, CMV cytomegalovirus, RIC reduced-intensity conditioning regimen
  2. aAs continuous variable