Fig. 3
From: Silencing of GATA3 defines a novel stem cell-like subgroup of ETP-ALL
GATA3low ETP-ALL exhibits a distinct transcriptional program. a Heat map of 1.5-fold DEG comparing GATA3low (n = 11) with GATA3high (n = 72) in patients with T-ALL (n = 83), including 30 patients with ETP-ALL and 53 patients with non-ETP-ALL. b–e GSEA restricted to ETP-ALL (n = 30) comparing GATA3low (n = 11) and GATA3high ETP-ALL (n = 19) revealed enrichment of ETP-ALL genes (NES = 1.5, p < 0.01) (b), depletion of T cell differentiation genes (NES = 1.6, p < 0.008) (c), enrichment of GMP-based genes (NES = 1.5, p = 0.06) (d), and enrichment of MLP-based genes (NES = 1.5, p = 0.04) in GATA3low ETP-ALL (e)