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Table 1 Inhibitory effect of alantolactone on different leukemia cell lines

From: Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells

Cell lines

IC50 (μM)a

Alantolactone

ADR

K562

2.75 ± 0.64

0.15 ± 0.08

K562/A02

2.73 ± 0.83

8.94 ± 3.79

HL60

3.26 ± 0.88

0.027 ± 0.022

HL60/ADR

3.28 ± 0.80

5.54 ± 1.21

THP-1

2.17 ± 0.72

0.06 ± 0.038

KG1a

2.75 ± 0.65

0.62 ± 0.15

Normal cell

26.37 ± 4.04

N/A

  1. ADR adriamycin, used as a positive control
  2. aAll values are the mean of three independent experiments