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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Immune biomarkers of treatment failure for a patient on a phase I clinical trial of pembrolizumab plus radiotherapy

Fig. 2

CT scans of the patient demonstrate disease progression. a Axial and coronal CT images taken before treatment. The white arrow indicates the target lesion, which was biopsied before and after RT. This lesion in the left anterior chest wall measured 20 × 13 mm. Other nodules included the right lower lobe lesion measuring 8 × 8 mm and the right lung base measuring 5 × 2 mm. b Axial and coronal CT images of patient 3 months post-treatment demonstrating disease progression. The left anterior chest wall mass increased from 20 × 13 mm to 24 × 21 mm. The right lower lobe nodule increased in size from 8 × 8 mm to 18 × 16 mm, and the right lung base increased from 5 × 2 mm to 11 × 13 mm. c Axial and coronal CT images 4 months post-treatment were performed to rule out pseudoprogression. True radiographic progression was confirmed. The left anterior chest wall mass increased from 24 × 21 mm to 30 × 29 mm. The right lower lobe nodule remained 18 × 16 mm, and the right lung base increased from 11 × 13 mm to 17 × 12 mm. d Schema displaying the patient’s course of treatment. The patient was randomized to group A2. He received no pembrolizumab pre-treatment, 20 Gy of radiation delivered over the course of five treatments followed by 200 mg of pembrolizumab every 3 weeks until disease progression

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