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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: The novel thiosemicarbazone, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and in vivo via multiple mechanisms

Fig. 2

DpC has more potent cytotoxic effects than Dp44mT and L1 on a neoplastic, neuroblastoma cell line, SK-N-LP, than a panel of non-tumorigenic, immortalized cells (i.e., MSC, HSC2, MIHI, HK2). In vitro cellular proliferation was assessed by the XTT assay comparing a panel of non-tumorigenic, immortalized cells and a neuroblastoma cell line incubated with either DpC, Dp44mT, or L1. a The effect of DpC, Dp44mT, or L1 (25 μM) on proliferation and viability as a function of time relative to control media alone (24–72 h/37 °C). b The effect of DpC, Dp44mT, or L1 at concentrations of 2.5, 25, and 250 μM on proliferation and viability relative to control medium alone after a 24 h/37 °C incubation. Data are presented as mean ± SEM (n = 3)

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