|
Adverse events
|
Grade 1/2
|
Grade 3
|
|---|
|
First 2 cycles
|
All cycles
|
First 2 cycles
|
All cycles
|
|---|
|
No. of patients
|
%
|
No. of patients
|
%
|
No. of patients
|
%
|
No. of patients
|
%
|
|---|
|
Occurred at least one time
|
21
|
100
|
21
|
100
|
2
|
10
|
6
|
29
|
|
Hand-foot skin reaction
|
4
|
19
|
10
|
48
|
0
|
0
|
1
|
5
|
|
Rash
|
4
|
19
|
6
|
29
|
0
|
0
|
0
|
0
|
|
Hypertension
|
5
|
24
|
5
|
24
|
0
|
0
|
2
|
10
|
|
Proteinuria
|
5
|
24
|
14
|
67
|
0
|
0
|
0
|
0
|
|
Triglyceride elevation
|
6
|
29
|
11
|
52
|
1
|
5
|
2
|
10
|
|
Total cholesterol elevation
|
6
|
29
|
13
|
62
|
0
|
0
|
0
|
0
|
|
Hypothyroidism
|
8
|
38
|
12
|
57
|
0
|
0
|
0
|
0
|
|
Hyperthyroidism
|
2
|
10
|
2
|
10
|
0
|
0
|
0
|
0
|
|
ALT elevation
|
6
|
29
|
10
|
48
|
0
|
0
|
0
|
0
|
|
AST elevation
|
4
|
19
|
9
|
43
|
0
|
0
|
0
|
0
|
|
Creatinine elevation
|
1
|
5
|
2
|
10
|
0
|
0
|
0
|
0
|
|
Total bilirubin elevation
|
5
|
24
|
8
|
38
|
0
|
0
|
0
|
0
|
|
Lipase elevation
|
1
|
5
|
5
|
24
|
1
|
5
|
1
|
5
|
|
Serum amylase
|
4
|
19
|
9
|
43
|
0
|
0
|
0
|
0
|
|
Myocardial enzymes abnormal
|
2
|
10
|
3
|
14
|
0
|
0
|
0
|
0
|
|
Leukopenia
|
3
|
14
|
6
|
29
|
0
|
0
|
0
|
0
|
|
Neutropenia
|
0
|
0
|
2
|
10
|
0
|
0
|
0
|
0
|
|
Thrombocytopenia
|
0
|
0
|
2
|
10
|
0
|
0
|
0
|
0
|
|
Hemorrhage
|
0
|
0
|
1
|
5
|
0
|
0
|
0
|
0
|
|
Urine occult blood
|
5
|
24
|
8
|
38
|
0
|
0
|
0
|
0
|
|
Fatigue
|
5
|
24
|
7
|
33
|
0
|
0
|
0
|
0
|
|
Diarrhea
|
6
|
29
|
7
|
33
|
0
|
0
|
0
|
0
|
|
Hoarseness
|
3
|
14
|
5
|
24
|
0
|
0
|
0
|
0
|
|
Nausea
|
3
|
14
|
3
|
14
|
0
|
0
|
0
|
0
|
|
Inappetence
|
1
|
5
|
2
|
10
|
0
|
0
|
0
|
0
|
|
Toothache
|
1
|
5
|
4
|
19
|
0
|
0
|
0
|
0
|
|
Pharyngalgia
|
1
|
5
|
4
|
19
|
0
|
0
|
0
|
0
|
|
Premature beat
|
0
|
0
|
1
|
5
|
0
|
0
|
0
|
0
|
-
ALT alanine aminotransferase, AST aspartate transaminase
