Adverse events | Grade 1/2 | Grade 3 | ||||||
---|---|---|---|---|---|---|---|---|
First 2 cycles | All cycles | First 2 cycles | All cycles | |||||
No. of patients | % | No. of patients | % | No. of patients | % | No. of patients | % | |
Occurred at least one time | 21 | 100 | 21 | 100 | 2 | 10 | 6 | 29 |
Hand-foot skin reaction | 4 | 19 | 10 | 48 | 0 | 0 | 1 | 5 |
Rash | 4 | 19 | 6 | 29 | 0 | 0 | 0 | 0 |
Hypertension | 5 | 24 | 5 | 24 | 0 | 0 | 2 | 10 |
Proteinuria | 5 | 24 | 14 | 67 | 0 | 0 | 0 | 0 |
Triglyceride elevation | 6 | 29 | 11 | 52 | 1 | 5 | 2 | 10 |
Total cholesterol elevation | 6 | 29 | 13 | 62 | 0 | 0 | 0 | 0 |
Hypothyroidism | 8 | 38 | 12 | 57 | 0 | 0 | 0 | 0 |
Hyperthyroidism | 2 | 10 | 2 | 10 | 0 | 0 | 0 | 0 |
ALT elevation | 6 | 29 | 10 | 48 | 0 | 0 | 0 | 0 |
AST elevation | 4 | 19 | 9 | 43 | 0 | 0 | 0 | 0 |
Creatinine elevation | 1 | 5 | 2 | 10 | 0 | 0 | 0 | 0 |
Total bilirubin elevation | 5 | 24 | 8 | 38 | 0 | 0 | 0 | 0 |
Lipase elevation | 1 | 5 | 5 | 24 | 1 | 5 | 1 | 5 |
Serum amylase | 4 | 19 | 9 | 43 | 0 | 0 | 0 | 0 |
Myocardial enzymes abnormal | 2 | 10 | 3 | 14 | 0 | 0 | 0 | 0 |
Leukopenia | 3 | 14 | 6 | 29 | 0 | 0 | 0 | 0 |
Neutropenia | 0 | 0 | 2 | 10 | 0 | 0 | 0 | 0 |
Thrombocytopenia | 0 | 0 | 2 | 10 | 0 | 0 | 0 | 0 |
Hemorrhage | 0 | 0 | 1 | 5 | 0 | 0 | 0 | 0 |
Urine occult blood | 5 | 24 | 8 | 38 | 0 | 0 | 0 | 0 |
Fatigue | 5 | 24 | 7 | 33 | 0 | 0 | 0 | 0 |
Diarrhea | 6 | 29 | 7 | 33 | 0 | 0 | 0 | 0 |
Hoarseness | 3 | 14 | 5 | 24 | 0 | 0 | 0 | 0 |
Nausea | 3 | 14 | 3 | 14 | 0 | 0 | 0 | 0 |
Inappetence | 1 | 5 | 2 | 10 | 0 | 0 | 0 | 0 |
Toothache | 1 | 5 | 4 | 19 | 0 | 0 | 0 | 0 |
Pharyngalgia | 1 | 5 | 4 | 19 | 0 | 0 | 0 | 0 |
Premature beat | 0 | 0 | 1 | 5 | 0 | 0 | 0 | 0 |