Fig. 4
From: DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1
Abrogation of D3Amut exerts an anti-infiltration effect. a Quantitative luciferase bioluminescence is monitored at day 30 post xenografting. Values are as mean ± SEM (n = 6 per group). Representative bioluminescent image of mice transplanted with OCI-AML3 cells stably expressing control shRNA (shControl) or shRNA-targeting DNMT3A (shDNMT3A). b Kaplan-Meier analysis shows the survival rates of mice receiving OCI-AML3 cells stably expressing a non-targeting shControl or an shDNMT3A