Fig. 1

S109 inhibits the proliferation and colony formation ability of glioma cells. a Kaplan-Meier analysis of overall survival for the French data. CRM1 had high expression in 131 out of 273 cases of glioma was associated with poor patient survival. b Structure of S109 and assessment of cell viability. Cells were treated with vehicle or various concentrations of S109 for 72 h. The cell viability was measured using CCK-8 assays. c Total protein extracts isolated from non-tumorous brain tissues and glioma tissues were evaluated through western blotting assays. d Representative images from the EdU analysis of cell proliferation after treatment of U87 cells with S109. f, h S109 suppresses colony formation of U87 and U251 cells in a dose-dependent manner. e, g, i Quantitative results of the EdU incorporation and clonogenic assays of U87 and U251 cells