PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma

Table 3 Univariate and multivariate analyses of prognostic factors in patients with NK/T-cell lymphoma (model 2)

Variable	Progression-free survival			Overall survival
	Univariate analysis	Multivariate analysis		Univariate analysis	Multivariate analysis
	P value	HR (95 % CI)	P value	P value	HR (95 % CI)	P value
Gender (female vs. male)	0.025	2.61 (1.13–6.02)	0.025	0.010
Age (>60 vs. ≤60 years)	0.660			0.887
ECOG score (≥2 vs. 0–1)	0.124			0.015
Stage (II vs. I)	0.001			0.003
B symptoms (yes vs. no)	0.251			0.264
LDH (elevated vs. normal)	0.020	2.26 (1.01–5.07)	0.048	0.001
IPI (2 vs. 0–1)	0.006			0.001	4.29 (1.48–12.41)	0.007
NKPI (2–3 vs. 0–1)	0.095			0.058
Chemotherapy (GELOX vs. CHOP-L)	0.661			0.800
Treatment response (non-CR vs. CR)	0.001			0.001
Histological PD-L1 (≥38 vs. <38 %)	<0.001	6.76 (2.91–15.69)	<0.001	<0.001	7.34 (2.36–22.86)	0.001

Abbreviations: CI confidence interval, CR complete remission, ECOG Eastern Cooperative Oncology Group, HR hazard ratio, IPI International Prognostic Index, LDH lactate dehydrogenase, NKPI natural killer/T-cell lymphoma prognostic index

ISSN: 1756-8722