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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

Fig. 1

Effect of BKM120 and BEZ235 on phosphorylation of PI3K/AKT/mTOR and MAPK pathway proteins. T cell-enriched PBMCs were stimulated for 48 h with anti-CD3 and anti-CD28 mAbs in the presence of different concentrations of BKM120 or BEZ235. Analysis of phosphorylation and expression of different proteins belonging to PI3K/AKT/mTOR and MAPKs pathways was performed. Western blot representative of at least three independent experiments

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