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Table 1 Histologic criteria for GvHD score

From: Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

Score

Skin

Liver

Large intestine

0

Normal

Normal

Normal

0.5

 

Focal mild portal lymphoid infiltrate

Occasional or rare necrotic cells in glands or crypts

1

Basal vacuolar change

Widespread mild portal lymphoid infiltrate

Isolated apoptotic epithelial cells, without crypt loss

2

Dyskeratotic cells in the epidermis and/or follicle, dermal lymphocytic infiltrate

Focal bile duct invasion or cellular injury

Individual crypt loss. Regeneration changes

3

Fusion of basilar vacuoles to form clefts and microvesicles

Multiple foci of bile duct injury and regeneration

Contiguous area of multiple crypt loss

4

Separation of the epidermis from the dermis

Widespread injury and destruction of bile ducts

Extensive crypt dropout with denudation of epithelium