Score | Skin | Liver | Large intestine |
---|---|---|---|
0 | Normal | Normal | Normal |
0.5 | Focal mild portal lymphoid infiltrate | Occasional or rare necrotic cells in glands or crypts | |
1 | Basal vacuolar change | Widespread mild portal lymphoid infiltrate | Isolated apoptotic epithelial cells, without crypt loss |
2 | Dyskeratotic cells in the epidermis and/or follicle, dermal lymphocytic infiltrate | Focal bile duct invasion or cellular injury | Individual crypt loss. Regeneration changes |
3 | Fusion of basilar vacuoles to form clefts and microvesicles | Multiple foci of bile duct injury and regeneration | Contiguous area of multiple crypt loss |
4 | Separation of the epidermis from the dermis | Widespread injury and destruction of bile ducts | Extensive crypt dropout with denudation of epithelium |