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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway

Fig. 1

Nelarabine induces cytotoxic effects in T-ALL cell lines. a Cell viability was assessed by MTT analysis of T-ALL cell lines treated for 48 h with increasing concentrations of nelarabine. Results are the mean of at least three different experiments ± SD. b Identification of nelarabine sensitive and resistant cell lines based on IC50 values. c MTT analysis of T-ALL cell lines treated with nelarabine or Ara-G, at the same increasing concentrations for 48 h. Results are the mean of at least three different experiments ± SD. d Flow cytometric analysis of absolute cell count with eBeads123 and PI exclusion of T-ALL cells treated with nelarabine for 48 h. All 13 cell lines shown in Fig. 1a (five sensitive and eight resistant) were analyzed. Data were plotted and grouped. Results are the mean of three different experiments ± SD. Asterisks indicate statistically significant differences with respect to untreated cells (***P < 0.001)

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