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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: T cells in multiple myeloma display features of exhaustion and senescence at the tumor site

Fig. 3

Accumulation of highly activated but senescent CD8+ T cells in the BM of myeloma patients. The expression of CD28 and CD57 was assessed on CD8+ T cells from patients with multiple myeloma and healthy, age-matched controls. Percentages of a CD8+CD28− T cells or b CD8+CD57+ T cells in healthy (n = 12) and myeloma samples (n = 12). c Percentages of CD8+CD57+CD28− T cells compared to CD8+CD57+CD28+ T cells (n = 10). d Concomitant expression of CD57 and PD-1 on CD8+ T cells of the BM of healthy and diseased (n = 6–8). Median with IQR is shown. Significance levels *p < 0.05; **p < 0.01; ***p < 0.001; n.s. not significant

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