Fig. 5
From: T cells in multiple myeloma display features of exhaustion and senescence at the tumor site
Proliferation of T cells in myeloma BM expressing CD57. Proliferation was determined by measuring dilution of CFSE using flow cytometry. Representative plots are shown for CD8+ T cells of (a) a healthy person, b a naive, and (c) a treated myeloma patient. The graphs display the results of independent experiments performed on samples from a four healthy persons, b seven chemo-naive, and c three treated patients (who were off IMiD-containing therapy for at least 6 months), showing the percentage of CD8+ T cells within each cell division. On the x-axis, the number of cell divisions according to CFSE dilution is indicated (G0 undivided; G1-3 1–3 cell divisions; significance levels *p < 0.05; **p < 0.001)