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Table 3 T cell subset distribution in BM aspirates and PB of myeloma patients and healthy persons

From: T cells in multiple myeloma display features of exhaustion and senescence at the tumor site

 

BM

PB

Healthy

Median % (IQR)

Myeloma

Median % (IQR)

Healthy

Median % (IQR)

Myeloma

Median % (IQR)

CD4+ T cells

CD45RA+/CD62L+ (Tn)

24.1 (13.2–39.10)

26.0 (14.5–36.4)

n.s.

18.1 (14.0–39.8)

25.7 (14.4–42.9)

n.s.

CD45RA−/CD62L+ (Tcm)

44.6 (37.2–48.2)

35.0 (19.4–52.6)

n.s.

48.8 (43.3–61.3)

42.4 (31.6–60.0)

n.s.

CD45RA−/CD62L− (Tem)

26.0 (22.1–32.2)

23.2 (9.2–36.3)

n.s.

18.7 (13.3–21.8)

15.6 (9.8–25.9)

n.s.

CD45RA+/CD62L− (Temra)

4.5 (2.4–6.2)

6.2 (2.0–16.8)

n.s.

2.9 (0.9–3.9)

2.4 (0.4–7.0)

n.s.

CD8+ T cells

CD45RA+/CD62L+ (Tn)

11.3 (7.6–18.4)

18.5 (10.3–24.7)

n.s.

14.8 (9.2–28.2)

26.3 (15.7–53.5)

n.s.

CD45RA−/CD62L+ (Tcm)

13.2 (9.8–17.1)

10.2 (7.0–15.3)

n.s.

23.5 (18.6–34.5)

19.4 (12.5–36.9)

n.s.

CD45RA−/CD62L− (Tem)

49.6 (40.0–66.2)

27.2 (19.8–38.9)

**

30.1 (27.1–44.0)

18.5 (11.3–32.4)

*

CD45RA+/CD62L− (Temra)

18.7 (15.1–27.9)

34.5 (25.7–52.4)

**

19.0 (11.4–32.3)

20.6 (7.7–31.3)

n.s.

  1. Percentages of the various T cell subsets in PB and BM were determined by flow cytometric analyses and are presented as median percentage with IQR (n = 12–16). Statistical significance was calculated using Mann-Whitney U test
  2. Tn naïve T cell, Tcm central memory T cell, Tem effector memory T cell, Temra effector T cell, n.s. not significant
  3. *p < 0.05; **p < 0.01