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Table 3 T cell subset distribution in BM aspirates and PB of myeloma patients and healthy persons

From: T cells in multiple myeloma display features of exhaustion and senescence at the tumor site

  BM PB
Healthy
Median % (IQR)
Myeloma
Median % (IQR)
Healthy
Median % (IQR)
Myeloma
Median % (IQR)
CD4+ T cells
CD45RA+/CD62L+ (Tn) 24.1 (13.2–39.10) 26.0 (14.5–36.4) n.s. 18.1 (14.0–39.8) 25.7 (14.4–42.9) n.s.
CD45RA−/CD62L+ (Tcm) 44.6 (37.2–48.2) 35.0 (19.4–52.6) n.s. 48.8 (43.3–61.3) 42.4 (31.6–60.0) n.s.
CD45RA−/CD62L− (Tem) 26.0 (22.1–32.2) 23.2 (9.2–36.3) n.s. 18.7 (13.3–21.8) 15.6 (9.8–25.9) n.s.
CD45RA+/CD62L− (Temra) 4.5 (2.4–6.2) 6.2 (2.0–16.8) n.s. 2.9 (0.9–3.9) 2.4 (0.4–7.0) n.s.
CD8+ T cells
CD45RA+/CD62L+ (Tn) 11.3 (7.6–18.4) 18.5 (10.3–24.7) n.s. 14.8 (9.2–28.2) 26.3 (15.7–53.5) n.s.
CD45RA−/CD62L+ (Tcm) 13.2 (9.8–17.1) 10.2 (7.0–15.3) n.s. 23.5 (18.6–34.5) 19.4 (12.5–36.9) n.s.
CD45RA−/CD62L− (Tem) 49.6 (40.0–66.2) 27.2 (19.8–38.9) ** 30.1 (27.1–44.0) 18.5 (11.3–32.4) *
CD45RA+/CD62L− (Temra) 18.7 (15.1–27.9) 34.5 (25.7–52.4) ** 19.0 (11.4–32.3) 20.6 (7.7–31.3) n.s.
  1. Percentages of the various T cell subsets in PB and BM were determined by flow cytometric analyses and are presented as median percentage with IQR (n = 12–16). Statistical significance was calculated using Mann-Whitney U test
  2. Tn naïve T cell, Tcm central memory T cell, Tem effector memory T cell, Temra effector T cell, n.s. not significant
  3. *p < 0.05; **p < 0.01