Table 3 Multivariate analysis of pre-transplant factors predicting for LFS, OS, and GRFS

Factor

HR

(95 % CI)

P value

HR

(95 % CI)

P value

HR

(95 % CI)

P value

RIC vs. MAC

0.88

(0.74–1.05)

0.15

0.78

(0.65–0.93)

0.01

1.03

(0.87–1.20)

0.75

CR2 vs. CR1

1.53

(1.23–1.91)

0.0001

1.59

(1.27–2.00)

0.00004

1.42

(1.16–1.74)

0.0008

Advanced vs. CR1

2.22

(1.86–2.66)

<0.00001

2.24

(1.87–2.68)

<0.00001

1.95

(1.64–2.31)

<0.00001

In vivo T cell depletion

1.16

(0.97–1.39)

0.10

1.10

(0.92–1.32)

0.31

0.84

(0.71–0.99)

0.04

Age >55 years

1.44

(1.22–1.69)

<0.00001

1.52

(1.29–1.80)

<0.00001

1.27

(1.09–1.47)

0.002

F → M

1.17

(0.99–1.38)

0.06

1.18

(0.99–1.40)

0.06

1.14

(0.97–1.33)

0.10

Cytogenetics

 Intermediate vs. good

1.12

(0.79–1.57)

0.53

1.10

(0.77–1.56)

0.59

1.08

(0.79–1.47)

0.63

 Poor vs good

1.72

(1.18–2.50)

0.005

1.51

(1.03–2.23)

0.04

1.58

(1.12–2.24)

0.01

 Missing

1.12

(0.77–1.62)

0.56

1.06

(0.72–1.55)

0.77

1.24

(0.88–1.74)

0.22

Year of SCT

0.97

(0.94–1.00)

0.06

0.96

(0.93–1.00)

0.03

0.97

(0.94–1.00)

0.08

Patient CMV +

1.05

(0.88–1.25)

0.58

1.09

(0.92–1.31)

0.32

0.98

(0.83–1.15)

0.77

Donor CMV +

0.96

(0.81–1.13)

0.59

0.93

(0.79–1.10)

0.41

0.99

(0.85–1.15)

0.90

PBSC vs. BM

0.84

(0.69–1.03)

0.10

0.87

(0.70–1.07)

0.18

1.05

(0.86–1.27)

0.64