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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

Fig. 1

The key knowledge gaps of the current caspase-1 model and the flow chart of our database mining strategy. a The key knowledge gaps between the current model and the newly proposed caspase-1 trafficking model. The new model suggests that caspase-1 may traffic to various subcellular organelles to interact and cleave its substrates and regulate variety of biological functions. b Flow chart of database mining strategy and three parts of data organization. We propose caspase-1 has two new working models: (1) caspase-1 gets activated in situ in the nucleus as novel nuclear inflammasome in response to intra-nuclear danger signals; (2) caspase-1 cleaves its substrates in exocytotic secretory pathways including exosomes to propagate inflammation to neighboring and remote cells

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