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Table 2 Pro-caspase-1 and inflammasome components traffic into nucleus and form active inflammasomes that activate caspase-1 in situ

From: Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

Inflammasome components

Function

Location

Translocation

PMID

ASC

ASC-b

Inflammasome adaptor

Cytoplasm

Nucleus

20482797

ASC-c

Inflammasome adaptor

Cytoplasm

Nucleus

ASC-d

 

Cytosol

Nucleus

Pro-caspase-1

Pro-caspase-1 and caspase prodomain promote translocation

Cytosol

Nucleus

9726961

NLRP3

Nuclear DNA-binding transcription factor

Cytosol

Nucleus

26098997

NLRA

Control transcription, inflammasome formation and transcriptional activity

 

Nucleus

26194278

NLRC5

Control transcription, inflammasome formation and transcriptional activity

 

Nuclear

26194278

  1. Abbreviation: ASC apoptosis-associated speck-like protein containing a carboxy-terminal CARD, NLR nucleotide-binding oligomerization domain-like (Nod)-like receptor, PMID PubMed identifier