Table 5 19/23 caspase-1 substrates are secreted in exosomes, where 8 of them were experimentally verified
Substrate | Location summary | Extracellular exosome | Inflammation | ||
|---|---|---|---|---|---|
Sourcea | PMID | Inflammatory function | PMID | ||
CA2 | Secreted | UniProtKB | Pro-inflammation | 7722336 | |
RNH1 | Secreted | UniProtKB | 19056867 | ||
IL18 | Secreted | UniProtKB | 23376485 | Pro-inflammation | 11203186 |
LDHB | Secreted | UniProtKB | |||
TBC1D15 | Secreted | UniProtKB | 23376485 | ||
IL1B | Secreted | UniProtKB | Pro-inflammation | 10380697 | |
FAA4 | Secreted | UniProtKB | |||
NUCB2 | Secreted | UniProtKB | Pro-inflammation | 16407280 | |
SYAP1 | Secreted | UniProtKB | 18570454 | ||
BID | Secreted | UniProtKB | Pro-inflammation | 17209037 | |
AK2 | Secreted | UniProtKB | 20458337 | ||
TPI1 | Secreted | UniProtKB | 19056867 | ||
PPP1CA | Secreted | ||||
ENO1 | Secreted | UniProtKB | Pro-inflammation | 19898480 | |
PSMA7 | Secreted | UniProtKB | |||
HUWE1 | Secreted | UniProtKB | 19056867 | ||
IL33 | Secreted | UniProtKB | Pro-inflammation | 18802081 | |
CAT | Secreted | UniProtKB | |||
CAP1 | Secreted | UniProtKB | 19056867 | Pro-inflammation | 24606903 |
ST14 | Secreted | UniProtKB | |||
IL37 | Secreted | Pro-inflammation | 22047735 | ||
ST14 | Secreted | ||||
NEDD4 | Secreted | ||||