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Table 1 Estimated IC50 of NSC 19630 in HTLV-1-transformed and patient-derived cells

From: WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells

HTLV-1-transformed cell lines IC50 (μM)
MT-4 1.99 ± 0.065
C8166 2.84 ± 0.19
C91PL 2.76 ± 0.28
1186.94 2.23 ± 0.3
ATL-derived cell lines IC50 (μM)
ED 0.75 ± 0.053
TL 1.73 ± 0.29
ATL-25 1.79 ± 0.22
ATL-43T 1.69 ± 0.23
ATL-55T 6.1 ± 0.15
LMY1 4.35 ± 0.21
KK1 1.64 ± 0.038
SO4 1.45 ± 0.12
KOB 1.73 ± 0.086
  1. We tested the HTLV-1-transformed, ATL-derived cell lines (MT-4, C8166, C91PL, 1186.94, ED, TL, ATL-25, ATL-43T, ATL-55T, LMY1, KK1, SO4, KOB) with increasing doses of NSC 19630 (0.2, 2, and 20 μM), and inhibition of cellular growth was measured by using cell count. We calculated the IC50 for every cell line by using logarithmic transformation and the values are reported in the table. Our analysis shows that ATL-55T and LMY1 were found to be less sensitive compared to the HTLV-1- and ATL-derived cell lines included in the study