|
HTLV-1-transformed cell lines
|
IC50 (μM)
|
|
MT-4
|
0.19 ± 0.042
|
|
C8166
|
0.22 ± 0.023
|
|
C91PL
|
0.21 ± 0.0091
|
|
1186.94
|
0.22 ± 0.063
|
|
ATL-derived cell lines
|
IC50 (μM)
|
|
ED
|
0.15 ± 0.033
|
|
TL
|
0.17 ± 0.039
|
|
ATL-25
|
0.16 ± 0.007
|
|
ATL-43T
|
0.099 ± 0.013
|
|
ATL-55T
|
0.22 ± 0.0012
|
|
LMY-1
|
0.29 ± 0.0087
|
|
KK1
|
0.28 ± 0.032
|
|
SO4
|
0.14 ± 0.061
|
|
KOB
|
0.17 ± 0.031
|
- We tested the HTLV-1-transformed, ATL-derived cell lines (MT-4, C8166, C91PL, 1186.94, ED, TL, ATL-25, ATL-43T, ATL-55T, LMY1, KK1, SO4, KOB) with increasing doses of NSC 617145 (0.02, 0.2, and 2 μM), and cell count was used to measure the inhibition of cellular growth. We calculated the IC50 for every cell line by using logarithmic transformation and the values are reported in the table. Our analysis clearly shows that NSC 617145 is more potent in inhibiting cellular proliferation compared to NSC 19630
