WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells

Table 2 Estimated IC50 of NSC 617145 in HTLV-1-transformed and patient-derived cells

We tested the HTLV-1-transformed, ATL-derived cell lines (MT-4, C8166, C91PL, 1186.94, ED, TL, ATL-25, ATL-43T, ATL-55T, LMY1, KK1, SO4, KOB) with increasing doses of NSC 617145 (0.02, 0.2, and 2 μM), and cell count was used to measure the inhibition of cellular growth. We calculated the IC50 for every cell line by using logarithmic transformation and the values are reported in the table. Our analysis clearly shows that NSC 617145 is more potent in inhibiting cellular proliferation compared to NSC 19630

ISSN: 1756-8722