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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

Fig. 4

TIGAR knockdown inhibited the proliferation of leukemia cells and sensitized leukemia cells to glycolysis inhibition in vitro. a The cell proliferation assay showed the cell growth of HL-60 cells with TIGAR knockdown in combination with Cocl2 or 2-DG. b The cell proliferation assay showed the cell proliferation of NB-4 cells with TIGAR knockdown in combination with Cocl2 or 2-DG. c, d The cell apoptosis rate was determined by FACS in both HL-60 (c) and NB-4 cells (d) with TIGAR knockdown in combination with Cocl2 or 2-DG. HL-60 and NB-4 cells with or without TIGAR knockdown were treated with Cocl2 or 2-DG. The cells were collected on day 2 post Cocl2 or 2-DG treatment, and the apoptotic cells were determined by FACS

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Journal of Hematology & Oncology

ISSN: 1756-8722

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