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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

Fig. 6

TIGAR expression and its anti-apoptotic effect were uncoupled from p53 in human leukemia cells. a Real-time PCR showed that the mRNA expression of TIGAR was not affected by p53 overexpression in both HL-60 and NB-4 cells. b Western blotting showed that the protein expression of TIGAR was not affected by p53 overexpression in both HL-60 and NB-4 cells. c The cell proliferation assay showed the cell growth of NB-4 cells with TIGAR knockdown in combination with p53 overexpression or/and MDM2 inhibitor Nutlin-3α. d TIGAR knockdown in combination with p53 overexpression or/and MDM2 inhibitor Nutlin-3α induced the apoptosis of NB-4 and HL-60 cells in vitro

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Journal of Hematology & Oncology

ISSN: 1756-8722

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