Fig. 4From: Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancerEffects of perifosine, gemcitabine and their combination on PDAC cells migration and invasion. a Results of wound-healing assay in LPC028 and LPC006 cells exposed to perifosine, gemcitabine or to their combination, at IC50 values for 24 h. b Results of invasion studies in the PDAC cells exposed for 24 h to perifosine, gemcitabine, or to their combination, at IC50 values (insert: representative pictures of LPC028 cells at 24 h, original magnification ×40). c Modulation of E-cadherin mRNA levels in LPC028, LPC006, PANC-1, and CFPAC-1 cells after 24-h exposure to perifosine, gemcitabine, or to their combination, at IC50 values, as determined by qRT-PCR. Columns or points mean values obtained from three independent experiments; bars, SEM. *Significantly different from controlsBack to article page