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Table 2 Function of nuclear-localized miRNAs relevant to human cancers

From: Nuclear microRNAs in normal hemopoiesis and cancer

Nuclear miRNA Function Cancer cells Reference
miR-10a Inhibit Hoxd4 to control cancer metastasis Breast cancer cell lines: MCF7 and MDA-MB-231 [39]
miR-483 Activate IGF2 to enhance tumorigenesis Wilms’ tumors [59]
miR-558 Activate HPSE to promote tumor growth Neuroblastoma cell lines: SK-N-SH, SK-N-AS, SH-SY5Y and SK-N-BE(2) [44]
miR-373 Increase expression of CDH1 tumor suppressor gene Prostate cancer cell line: PC3 [38]
miR-124 Activate tumor suppressor gene, P27 Breast and ovarian cancer cell lines: MDA-MB-231, HeyA8, SKOV3.ip1, SKBr3, OVCAR-3, BxPC-3 and L3.6pl, MIA PaCa 2, Panc1, U87, SNB19 and LN229 [60].
miR-205 Activate interleukin tumor suppressor genes, IL24 and IL32 Prostate cancer cell lines: PC3, LNCaP and Du145 [45].
miR-774 Promote transcription of Ccnb1 Mouse prostate adenocarcinoma cell line: TRAMP C1 [61]
miR-370 Activate tumor suppressor gene, P21 Bladder cancer cell lines: T24 and EJ [76]
miR-1180 Activate tumor suppressor gene, P21 Bladder cancer cell lines: T24 and EJ [76]
miR-1236 Activate tumor suppressor gene, P21 Bladder cancer cell lines: T24 and EJ [76]
miR-939 Repression of Bcl-xl anti-apoptosis gene Human neuroblastoma cell line: SH-SY5Y [62]