Table 2 Function of nuclear-localized miRNAs relevant to human cancers

miR-10a

Inhibit Hoxd4 to control cancer metastasis

Breast cancer cell lines: MCF7 and MDA-MB-231

[39]

miR-483

Activate IGF2 to enhance tumorigenesis

Wilms’ tumors

[59]

miR-558

Activate HPSE to promote tumor growth

Neuroblastoma cell lines: SK-N-SH, SK-N-AS, SH-SY5Y and SK-N-BE(2)

[44]

miR-373

Increase expression of CDH1 tumor suppressor gene

Prostate cancer cell line: PC3

[38]

miR-124

Activate tumor suppressor gene, P27

Breast and ovarian cancer cell lines: MDA-MB-231, HeyA8, SKOV3.ip1, SKBr3, OVCAR-3, BxPC-3 and L3.6pl, MIA PaCa 2, Panc1, U87, SNB19 and LN229

[60].

miR-205

Activate interleukin tumor suppressor genes, IL24 and IL32

Prostate cancer cell lines: PC3, LNCaP and Du145

[45].

miR-774

Promote transcription of Ccnb1

Mouse prostate adenocarcinoma cell line: TRAMP C1

[61]

miR-370

Activate tumor suppressor gene, P21

Bladder cancer cell lines: T24 and EJ

[76]

miR-1180

Activate tumor suppressor gene, P21

Bladder cancer cell lines: T24 and EJ

[76]

miR-1236

Activate tumor suppressor gene, P21

Bladder cancer cell lines: T24 and EJ

[76]

miR-939

Repression of Bcl-xl anti-apoptosis gene

Human neuroblastoma cell line: SH-SY5Y

[62]