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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell

Fig. 5

PP2A/MAPKK/MAPK axis was a BIR domain downstream effector responsible for its inhibition of c-Jun protein phosphorylation and activation. ac Whole cells lysis obtained from the indicated transfectants were subjected to Western blot for analysis of activation of the MAPKs (a) and MAPKKs (b) and expression of PP2A. GAPDH was used as the protein loading control. d The indicated cells were treated with Okadaic acid (OA) for 6 h, and whole cells lyses were subjected to Western blot for determination of protein expression. GAPDH was used as the protein loading control

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