Fig. 3
TTP (time to progression) values for control (CTRL), PRX177561, bevacizumab, and the combination in U87MG tumors (a), U251 tumors (d), and T98G tumors (g). Kaplan-Meier estimates for rates of progression in U87MG tumors (b), U251 tumors (e), and T98G tumors (h). Statistical analyses for U87MG tumors (c), U251 tumors (f), and T98G tumors (i). U87MG, U251, and T98G bearing nude mice were treated with bevacizumab (4 mg/kg iv every 4 days) alone or in combination with or PRX177561 (50 mg/kg po qd) in subcutaneous xenograft models. Tumors were randomized when they reached a volume of 100–150 mm3 and treated for 35 days. Tumors were measured every 2 days for a total of 17 measurements. After 35 days, animals were sacrificed and tumors harvested and weighed