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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma

Fig. 6

In vivo effects of CXCR4 antagonist, PRX177561, alone or in combination with bevacizumab or sunitinib in orthotopic intra-brain models: Disease-free survival (DFS) analyses. Luciferase-expressing U87 cells were injected in female nude mice as described, and 5 days after cell injection, when no bioluminescent lesions were visible, animals were randomly assigned to one of the six different treatment groups: (1) vehicle (control), (2) PRX177561, (3) bevacizumab, (4) PRX177561 plus bevacizumab, (5) sunitinib, and (6) sunitnib plus PRX177561. The presence of a bioluminescent signal was considered to define the DFS. After 35 days, treatments were stopped and animals were followed for the presence of bioluminescent positive lesions in order to calculate the DFS. a DSF graphical representation in our arms. b Kaplan-Meier rates analyzed for PRX177561 ± bevacizumab. c Kaplan-Meier rates analyzed for PRX177561 ± sunitinib. d Statistical analysis

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