Fig. 1
From: Is CD47 an innate immune checkpoint for tumor evasion?
Working model of CD47 blockade for enhancing antigen cross-presentation by dendritic cells and increased T cell priming. Upon CD47-SIRPa blockade, tumor cells are phagocytosed and their DNA can gain access to the cytosol of intratumoral dendritic cells. Recognition of cytosolic DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) and generation of cGAMP lead to the activation of STING, resulting in the production of type I IFN. DCs are activated by type I IFN to cross-present tumor antigens to CD8+ T cells, which then proliferate and kill tumor cells