Fig. 7
From: Novel roles of DC-SIGNR in colon cancer cell adhesion, migration, invasion, and liver metastasis
Liver metastasis formation. Colon cancer cells detach from the primary sites, circulate in the surrounding tissues, and enter the blood vessels (intravasation). The cells adhere to endothelial cells through the interaction between DC-SIGNR as a receptor on the surface of endothelial cells and the receptor ligand expressed on colon cancer cells. DC-SIGNR increases the expression of MT1M, MT1B, MT1G, MT1H, MT1X, MT1F, and MMP9 in colon cancer cells. Then, the cells are able to extravasate, migrate, invade into the nearby liver, and form the metastatic tumour