Fig. 3From: Prostate-specific IL-6 transgene autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri-prostatic adipose tissueIL-6 induces autocrine IL-6 secretion and upregulates IGF signaling axis in the prostate. a Quantitative RT-PCR demonstrating significantly increased mouse IL-6 (mIL-6) expression in the prostate of pbIL-6 mice in comparison to B6 WT littermates. b Significant elevation of serum mIL-6 in pbIL-6 mice in comparison to B6 WT littermates. c, d Significant elevation of IGF-I and IGF-II expression in the prostate of pbIL-6 mice in comparison to B6 WT littermates. Data shown were representatives of mice at the age of 26-week oldBack to article page