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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

Fig. 4

miR-34a induces a senescence-like phenotype in MP115 cells. a At 96 h following transfection of STO and MP115 cells with Ctrl, Neg, or miR-34a, nuclei were stained with propidium iodide and analyzed for DNA content by FACScan. Data (mean ± SD of three independent experiments) represent the percentage of cells in the different cell cycle phases. b Left panel: representative micrographs of SA-β-gal staining of STO and MP115 cells transfected with Neg or miR-34a. Blue precipitation in the cytoplasm was observed in the senescent cells. Original magnification, × 40. One representative experiment of three was shown. Right panel: histogram bars represent the mean percentage of SA-β-gal positive cells ± SD of at least three independent experiments (**p < 0.01 by Student’s t test)

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Journal of Hematology & Oncology

ISSN: 1756-8722

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