Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

Table 2 Effect of miR-34a reconstitution on DMPM cell tumorigenicity following i.p. injection in SCID mice

Model	miRNA	Day of sacrifice	Engrafted tumors/total mice^a	p value^b	Tumor weight (mg)	Average value	TVI (% Neg)^c	p value^d
STO	Neg	14	5/5		10, 80, 80, 100, 110	76
STO	miR-34a		1/5	0.0476	0, 0, 0, 0, 10	2	97	0.0029
MP8	Neg	31	5/5		130, 310,250, 210,150	210
MP8	miR-34a		5/5		80, 90, 70, 120, 80	88	58	0.0071

^aNumber of mice presenting i.p. tumors out of number of cell-injected mice
^bBy Fisher’s exact test over Neg cell-injected mice
^cTumor weight inhibition % in miRNA34a- over Neg-transfected cell-injected mice
^dBy Student’s t test over Neg-transfected cell-injected mice

ISSN: 1756-8722