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Table 2 Effect of miR-34a reconstitution on DMPM cell tumorigenicity following i.p. injection in SCID mice

From: Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

Model miRNA Day of sacrifice Engrafted tumors/total micea p valueb Tumor weight (mg) Average value TVI (% Neg)c p valued
STO Neg 14 5/5   10, 80, 80, 100, 110 76   
miR-34a   1/5 0.0476 0, 0, 0, 0, 10 2 97 0.0029
MP8 Neg 31 5/5   130, 310,250, 210,150 210   
miR-34a   5/5   80, 90, 70, 120, 80 88 58 0.0071
  1. aNumber of mice presenting i.p. tumors out of number of cell-injected mice
  2. bBy Fisher’s exact test over Neg cell-injected mice
  3. cTumor weight inhibition % in miRNA34a- over Neg-transfected cell-injected mice
  4. dBy Student’s t test over Neg-transfected cell-injected mice