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Table 2 Phenotypic analysis of lymphocyte population in long-term responders (group A, n = 5) and non-responders/relapse or necessitating immunosuppression (group B, n = 5) systemic sclerosis patients after autologous hematopoietic stem cell transplantation

From: Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients

Lymphocyte population Normal range (cell counts/ml) At inclusion 2–3 years 4–5 years Long term
Group A Group B Group A Group B Group A Group B Group A Group B
Total 1718–2620 1862 ± 764 1318 ± 748 1348 ± 777 1034 ± 584 1408 ± 937 1135 ± 482 1579 ± 616 1316 ± 624
T cells (CD3+) 1008–1647 1135 ± 485 957 ± 629 937 ± 569 713 ± 477 917 ± 561 749 ± 440 1417 ± 187 1143 ± 527
CD4 T cells (CD3+CD4+) 587–1009 730 ± 163 563 ± 373 409 ± 269 405 ± 305 510 ± 315 412 ± 269 678 ± 345 576 ± 367
Naive CD4 T cells (CD4 + CD45RA+) 161–529 195 ± 161 145 ± 44 197 ± 171 152 ± 221 187 ± 193 158 ± 218 372 ± 175 290 ± 271
CD8 T cells (CD3+CD8+) 313–644 459 ± 182 345 ± 228 453 ± 259 282 ± 171 410 ± 245 299 ± 153 571 ± 39 443 ± 185
B cells (CD19+) 121–267 70 ± 53* 119 ± 91* 300 ± 391 137 ± 137 175 ± 56 208 ± 214 188 ± 63 197 ± 217
NK cells (CD3-CD16+CD56+) 82–340 176 ± 108 112 ± 34 151 ± 64* 92 ± 113* 115 ± 55 132 ± 100 150 ± 92 135 ± 101
  1. Lymphocyte immonophenotyping was performed on fresh whole blood EDTA samples by direct eight-color immunofluorescence flow cytometry. Results are expressed as absolute numbers (mean ± SD) of cell counts/ml
  2. *P = 0.014 between the groups (two-tailed Mann-Whitney)