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Table 5 Multivariate analyses

From: Impact of in vivo T cell depletion in HLA-identical allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission conditioned with a fludarabine iv-busulfan myeloablative regimen: a report from the EBMT Acute Leukemia Working Party

 

Chronic GVHD

NRM

Relapse

LFS

OS

GRFS

p value

OR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

p value

HR (95% CI)

In vivo T cell depletion

0.0001

0.46 (0.31–0.68)

0.094

0.59 (0.32–1.09)

0.149

0.72 (0.46–1.12)

0.027

0.67 (0.46–0.95)

0.027

0.65 (0.44–0.95)

4 × 10−5

0.51 (0.37–0.70)

Age at SCT >50 years

0.447

1.13 (0.82–1.57)

0.012

1.83 (1.14–2.94)

0.083

1.39 (0.96–2.00)

0.004

1.53 (1.15–2.05)

0.026

1.42 (1.04–1.93)

0.037

1.32 (1.02–1.71)

Interval diag. to SCTa

0.465

1.05 (0.91–1.22)

0.209

1.00 (1.00–1.00)

0.974

1.00 (1.00–1.00)

0.461

1.00 (1.00–1.00)

0.410

1.00 (1.00–1.00)

0.717

1.00 (1.00–1.00)

Year of SCT

0.929

1.00 (1.00–1.00)

0.894

0.99 (0.87–1.30)

0.862

1.01 (0.91–1.12)

0.960

1.00 (0.92–1.09)

0.558

0.98 (0.90–1.06)

0.522

0.98 (0.91–1.05)

Secondary AML

0.033

1.68 (1.04–2.72)

0.232

1.55 (0.76–3.19)

0.434

1.26 (0.71–2.26)

0.192

1.35 (0.86–2.12)

0.163

1.40 (0.87–2.25)

0.058

1.47 (0.99–2.18)

Female D to male R

0.001

1.75 (1.27–2.43)

0.669

1.12 (0.66–1.90)

0.319

1.22 (0.82–1.82)

0.306

1.18 (0.86–1.62)

0.253

1.21 (0.87–1.69)

0.0004

1.62 (1.24–2.11)

R CMV seropositivity

0.231

1.32 (0.84–2.09)

0.851

0.93 (0.46–1.90)

0.733

0.91 (0.55–1.53)

0.651

0.91 (0.60–1.38)

0.456

0.85 (0.55–1.31)

0.639

0.92 (0.64–1.32)

D CMV seropositivity

0.417

1.17 (0.81–1.68)

0.241

1.49 (0.77–2.89)

0.812

1.06 (0.67–1.68)

0.358

1. 20 (0.82–1.75)

0.359

1.21 (0.81–1.80)

0.832

1.04 (0.75–1.42)

Center (frailty variable)

0.0007

 

0.047

 

0.211

 

0.917

 

0.913

 

0.154

 
  1. AML acute myeloid leukemia, CMV cytomegalovirus, D donor, diag diagnosis, GRFS GVHD/relapse-free survival, GVHD graft-versus-host disease, LFS leukemia-free survival, NRM non-relapse mortality, OS overall survival, R recipient, SCT allogeneic stem cell transplantation
  2. aAnalyzed per 6-month interval